Look at our last article (pre-print) on the intrinsic impact of genome-wide epigenetic methylation!

The result of a long fruitful collaboration between several groups led to this final work where we studied the effects of CpG methylation at genome-scale using haploid yeast cells. Yeast lacks the required machinery to write, read and process 5-methyl-cytosine epigenetic modifications. We then expressed Murine DNA Methyl Transferases enzyme in yeast to study the intrinsic impact of genome-wide methylation.

Our work was to integrate two coarse-grained models of chromatin and chromosomes to HiC and MNase-seq experimental data and provide a 3D analysis of the reorganization of the yeast nucleus before and after methylation.

https://www.researchsquare.com/article/rs-36311/latest.pdf

The work is in revision at Nature Comm, so cross your fingers! Hope you like it. Your comments are always welcome!